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Comprehensive Biomarkers

$1,479.00

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Includes the following panels: CBC + CMP + Lipid + Full Thyroid (49 biomarkers), the DUTCH test for hormones, Iron/Ferritin, Macro Nutrients, Micronutrients, Vit D, Vitamin B (B1, B6, B9, B12)

This comprehensive panel of tests provides a thorough picture of your current health status and can help to identify any potential health concerns early on. Early detection is key to maintaining good health and avoiding serious health complications down the road.

 

The CBC (Complete Blood Count) test measures the number of white and red blood cells in your blood, as well as the amount of hemoglobin and platelets. This information can help your doctor diagnose problems such as anemia, infection, or leukemia.

The Comprehensive Metabolic Panel (CMP) measures various chemicals and metabolites in your blood, including glucose, creatinine, and cholesterol. This information can help you identify early signs of diabetes or heart disease. The Ferritin test measures the amount of iron stored in your body. Low ferritin levels can indicate an iron deficiency.

The Lipid Panel with Ratios measures various fats and cholesterol in your blood. This information can help you identify early signs of heart disease or diabetes.

Thyroid Panel with Thyroid-Stimulating Hormone (TSH):  Thyroid function is critical to your metabolism and affects your energy level, heart rate, weight control, and more. The thyroid-stimulating hormone is produced in the pituitary gland and stimulates the production of thyroid hormones. The TSH helps identify an underactive or overactive thyroid state. This comprehensive evaluation of your thyroid hormone levels includes T-3 Uptake, T4, and Thyroid-Stimulating Hormone (TSH).

Free T3:  Free T3 is for evaluating thyroid function and assessing abnormal binding protein disorders.

Free T4:  Free T4 may be indicated when binding globulin (TBG) problems are perceived, or when conventional test results appear to be inconsistent with clinical observations. It is normal in those with high thyroxine-binding globulin hormone binding who are euthyroid (i.e., free thyroxin should be normal in nonthyroidal diseases). It should also be normal in familial dysalbuminemic hyperthyroxinemia.

Thyroid Peroxidase (TPO) Antibodies:  Antibodies to thyroid microsomes (thyroid peroxidase) are present in 70% to 90% of patients with chronic thyroiditis. They are also present in smaller percentages of patients of other thyroid diseases. Antibody production may be confined to lymphocytes within the thyroid, and serum may be negative. Small numbers (3%) of people with no evidence of disease may have antibodies. This is more frequent in females and increases with age.

Thyroid Antithyroglobulin Antibody:  This test may be ordered to investigate the cause of an enlarged thyroid gland (goiter) or performed as a follow-up when other thyroid test results (such as T3, T4, and TSH) show signs of thyroid dysfunction. One or more thyroid antibody tests also may be ordered if a person with a known non-thyroid-related autoimmune condition, such as rheumatoid arthritis, systemic lupus erythematosus, or pernicious anemia, develops symptoms that suggest thyroid involvement. Such involvement may occur at any time during the course of the other condition(s).

Reverse triiodothyronine (rT3):  RT3 is an isomer of triiodothyronine (T3) with no demonstrated biological activity. The majority of rT3 is produced through peripheral enzymatic monodeiodination of T4 at the five positions of the inner ring of the iodothyronine nucleus of thyroxine (T4). A lesser amount of rT3 is secreted directly by the thyroid gland. T3 is biologically inactive and does not stimulate thyroid hormone receptors. Concentrations are elevated in chronic or acute diseases because of changes in peripheral rates of conversion of T4 to T3 and reverse T3. Drugs such as amiodarone and glucocorticoids cause increased levels of reverse T3. Reverse T3 levels are elevated at birth and will decline to normal levels by the first week of life. Measurement of reverse T3 may be of use in the assessment of thyroid function and metabolism in the newborn.

Thyroxine-binding Globulin (TBG):  TBG distinguishes between high T4 levels due to hyperthyroidism and due to increased binding by TBG in euthyroid individuals who have normal levels of free hormones; document cases of hereditary deficiency or increase of TBG; work-up of thyroid disease. In patients with low T4, high T3 (uptake), or the reverse, who clinically seem eumetabolic and have normal FTI, measurement of TBG is only occasionally needed. Some such patients may have genetic anomalies of TBG. TBG is increased by estrogens, tamoxifen, pregnancy, perphenazine, and in some cases of liver disease, including hepatitis. Decreased TBG is found with some instances of chronic liver disease, nephrosis, and systemic disease, and with large amounts of glucocorticoids, androgens/anabolic steroids, and acromegaly. Although alterations of TBG are usually resolved by the thyroid profile, TBG must occasionally be directly measured.

 

The DUTCH Complete takes hormone testing to a whole new level. This test looks at sex hormones and their metabolites, the overall diurnal pattern of free cortisol, and the total and distribution of cortisol metabolites in addition to OATs which provide insight into nutritional deficiencies, oxidative stress, gut dysbiosis, melatonin, neuroinflammation and more.

The DUTCH is an AT HOME test, this means no having to drive and schedule a time to get your test done at a lab!

 

HOW IS THIS DIFFERENT FROM OTHER HORMONE TESTS?

Easier Collection: Patients collect just four or five dried urine samples over a 24-hour period. Dried samples are stable for several weeks making them convenient to ship worldwide.

Comprehensive Report: DUTCH offers the most extensive profile of sex and adrenal hormones along with their metabolites. The comprehensive report gives providers actionable results so they can develop more effective treatment plans.

Backed by Research: Precision Analytical’s testing methods go through a rigorous validation process to verify accuracy, recovery, and linearity. We pride ourselves in relentlessly pursuing the most accurate and precise techniques available for testing.

Effective HRT Monitoring: DUTCH testing was designed to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones.

 

HOW DOES DUTCH COMPARE TO OTHER HORMONE TESTS?

DUTCH vs. Saliva Testing – While the free cortisol pattern in saliva has clinical value, there is a significant missing piece to surveying a patient’s HPA-Axis function with saliva testing – measuring cortisol metabolites. To properly characterize a patient’s cortisol status, free and metabolized cortisol should be measured to avoid misleading results when cortisol clearance is abnormally high or low. Likewise with sex hormones, measuring estrogen and androgen metabolites gives a fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring.

 

DUTCH vs. Serum Testing – While the most universally accepted testing method (due to the availability of FDAcleared analyzers that are reliable and inexpensive), serum testing is lacking in some areas. Adrenal hormones cannot be effectively tested in serum because free cortisol cannot be tested throughout the day. There is also a lack of extensive metabolite testing (especially for cortisol and estrogens).

 

DUTCH vs. 24-Hour Urine Testing – There are two primary drawbacks to 24-hour urine testing of hormones. First, the collection is cumbersome, and as many as 40% of those who collect, do so in error (Tanaka, 2002). Secondly, dysfunction in the diurnal pattern of cortisol cannot be ascertained from a 24-hour collection. Some providers add saliva for daily free cortisol. DUTCH eliminates the need for two tests

The Iron and Total Iron Binding Capacity (TIBC) test determines the concentration of iron in your blood as well as the amount of iron bound to proteins. TIBC is used to decide whether or not you have an iron deficiency or an iron overload.

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